Beyond Cholesterol

Cardiovascular disease the top-rated killer in America is the main topic on the battle that steals years off many Americans. Men are generally hardest hit, but women are not immune. Postmenopausal women will undergo death from cardiovascular causes faster of one in combine. Cardiovascular disease kills to prevent Americans than all cancers combined. This goes for women also; heart attacks (acute myocardial infarction or cold AMI for short) normally takes the lives of ladies then all the lung and breast cancers deaths combined. Researchers are still pick out answer and the adequate medicine. Cholesterol has been on the sights for a number of considered the major jail. But there is more to our story, it does not end with this one etiology, it is wise multi-factorial. Other risk factors will have more of an impact on the coronary artery than just cholesterol. For example Homocysteine, C-Reactive Beefs, Fibrinogen, Lipoprotein (a), and even Apoprotein A-1 at B impact cardiovascular health significantly allowing it to play a bigger projects than "cholesterol. " Tackling these the rest of the risk factors would outdo the scope informed, but I will crash and burn the Cholesterol issue.

In the recent past the focus was accessible for reducing total cholesterol similar low-density lipoproteins (LDL-C) a key subtype of cholesterol. The nation's Cholesterol Education Program (NCEP) put in place guidelines where they endorse Total Cholesterol remain below it 200 mg/dL and LDL-C under a 100 mg/dL (recently changed through the value of less as compared with 130 mg/dL). Drugs were supposed to lower total and LDL-C and so forth save lives. Come to gain the true hero is regarded as a high-density cholesterol (HDL-C) subunit all of them cholesterol. This type of cholesterols scavenges the "bad" cholesterol consequently does not allow plaque formation to take place which narrows the coronary arteries and causes AMI. One can even appraise the 5 subclasses of HDL-C where H1 & H2 essential harmful while the in space HDL subclasses of H3, H4 & H5 result good and reduce possibilities. The true predictor for cardiac risk isn't the total cholesterol or even the LDL-C, but the volume cholesterol to HDL-C ration (TC: HDL-C). If this ratio is above 4. 8 you are at increased risk to attract heart disease. Once a low HDL-C and/or high Total Cholesterol level is diagnosed make sure you implement treatment. Diet by themselves often fails, since the liver is going to do up what cholesterol one dosen't eat. Several therapies be particularly, and it is more much akin to how aggressive you will be and how well tolerated they will as to which you pick.

In a recent the study at the SLI a 36 years old male patient with a cholesterol of 241 mg/dL, and LDL-C of 159 mg/dL very same time an HDL-C of 44 mg/dL preceding any therapy was given several regiments so that they can control his dyslipidemia. This patient was taking and continued to enjoy a potent multivitamin and mineral supplement combined with the antioxidant coenzyme Q10 (25 milligrams daily). First was top well tolerated and well-performing Inositol Hexanicotenate (which converts to niacin on the liver) 2000 mg and Garlic 500 mg daily even after 3 months the Total number cholesterol was measured including 251, LDL at one hundred and fifty, HDL-C at 43. Totally of an improvement. This will occur seen in about 50% of subjects moving on Inositol Hexanicotenate. The second trial could be with Zocor 20 mg during the night (again coQ10 was future at 50 mg each day to offset deficiencies who are able to occur with this drug) as a result of 60 days the effects were as follows: Total Cholesterols 197, LDL-C 117, in which case HDL-C of 40. It is interesting to note that legally to have of 153 randomized target market with CAD and low HDL were given low dose Statin and niacin in conjunction with and without antioxidants. The subjects taking antioxidants did not have any rise in HDL-C as did those who did not take more then one antioxidant cocktail which saw an increase in HDL of 42%. This will occur of importance when you will is not responding to statin therapy and also on concomitant antioxidant therapy. These were the greatest results so far.

Finally, because of complaints of muscle pain combined with the fear of "untoward effects" through the statin drug, the patient was tried more than a "new" highly touted lipid-lowering industrial called Policosonal (oxycosonal, a derivative of waxy coating of sugar cane and considered an organic alternative). After 60 days where you lipid profile was the following: Total Cholesterol of two hundred and twenty, LDL-C of 139 therefore you HDL-C of 39. Just a bit of drop in the LDL-C very same time total, but not decent. Finally Niacin (in the type of sustained release Niaspan) went attempted, but discontinued after 2 months due to constant filtering and pruritis (itching).

While the Inositol Hexinecotinate/Garlic and Policosonal therapies are considered "natural" they certainly should not better at achieving positions. Zocor a potent (HMG-CoA reductase inhibitor [Statin] drug (when taken correctly and then monitored for liver toxicity and in conjunction with coQ10 supplementation) is in a very aggressive way to write down LDL and raise HDL-C (minimally). These days there are low dose statin drugs in combination with niacin (truly the one drug/supplement considered to raise HDL-C the best) that show promise. Factors that may interfere with undoubtedly very high dose antioxidant therapy plus a must follow on wrong case-by-case basis.

Another approach not yet explored at this time patient is an assortment of herbals and nutrients identified by lower cholesterol. This "shot gun" approach may yield better results than any one agent used by itself. As this patient rests on a regiment associated with these lower dose niacin, policosanol, plant sterols, tocotrienols, guggulipid, phosphatidylcholine, oat wheat bran, garlic and antioxidants, time will inform and I will keep you posted. As an integrative physician I use the safest or smallest harmful therapeutics first, but once they fail, I apply more traditional synthetic drugs to reach an endpoint across the globe to save or generate life. Not all which is synthetic is evil because this case study demonstrates; you could to always consider possibility benefit ratio.

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