After years of understanding that high cholesterol can lead to coronary artery disease, and attempts to reduce cholesterol levels by diet, exercise and medications, we are finally starting to acquire a pretty good understanding of ways to lower cholesterol should you patients with hypercholesterolemia.
First it is helpful to acquire a basic understanding of the kinds of cholesterol particles in their bloodstream. When we eat the nutrients we ingest are absorbed right out the small intestine and end up having capillaries and veins featuring a liver, using what referred to as the portal circulation. This strong blood is filtered of this liver where the fat we ingest is manufactured with proteins into particles called lipoproteins ("lipo" finally behind fat + "protein" for protein) Protein requires a higher density than excess fat, and so particles which contains mostly cholesterol are defined low density lipoproteins including LDL, and those which contains a higher concentration s of protein, are high size lipoproteins or HDL. Although the full story is a lot more complex, in general you want to have lots of HDL, and not much HIGH LEVELS OF.
As of this time we are not very good at helping patients increase their HDL cholesterol. Exercise, body fat, and some medications consisting of niacin can increase HDL modestly, but in general we do not have highly effective drugs to increase a person's HDL levels of cholesterol.
LDL cholesterol is a third party matter. A class of medications referred to as "statins" which includes varieties of generic and branded prescriptions, all work to put a stop to the enzyme HMG-CoA Reductase. This enzyme plays fundamental role in the production of LDL cholesterol in the actual usage of liver, and so by blocking its function much less LDL cholesterol arises from the liver. Many research shows that use of statins to save on LDL cholesterol can reduce second heart attacks in patients who have had a prior episode.
Most patients tolerate the statin band of medications well, but muscle pain is a fairly common side effect, and often include significant pain and shortcoming. In some patients use of pravastatin of red abolish rice which has small amounts of lovastatin produced naturally is principally tolerated when other statins cause unacceptable unwanted side effects.
The role of statins in major prevention, i. e. patients without prior heart attacks, is not as well proven beyond doubt beneficial, but is still extraordinarily preferred in hopes of becoming less cardiovascular risk.
Dr Pullen MD
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